Anti inflammatory activity thesis
Currently, Aloe ferox is accepted not only in South Africa or Africa but internationally for its effective antiseptic, cleansing, and anti-inflammatory properties.
Therefore, the selective inhibition of LOX is an important therapeutic strategy for asthma [ 81624 ]. Specifically, the result showed that D. Lesotho Lesotho is one of the countries in southern Africa and traditional medicine plays a key role in meeting the health needs of the rural population.
Recent studies on Zingiber officinale, ginger, suggest that it might be as effective as some NSAIDs in the treatment of inflammation and related pain [ 78 ].
Based on the role of free radicals in inflammatory processes, the authors suggested that the anti-inflammatory effect of the extract may be partly linked to its antioxidant content since the extract is very rich in phenolic compounds. Phytochemical screening of the plants shows the presence of alkaloids, saponins, glycosides, cardiac glycosides, and steroidal nucleus.
Unfortunately, there are many side effects associated with the administration of nonsteroidal anti-inflammatory drugs.
Various investigators have reported on the inhibition of pro-inflammatory cytokines following the feeding of rats with plant extracts that are rich in flavonoids. Anti-inflammatory activity of each plant extract was assessed by using COX assay.
Vetrighelvan T, Jegedeesan M. Excessive production of inflammatory mediators may lead to chronic disease. Hassan and colleagues examined the anti-inflammatory activities of five Nigerian plants.
Determination of anti inflammatory activity
Kulkarni SK. Saponins are different groups of natural glycosides that are produced primarily by plants, lower marine animals, and certain bacteria. Effect of alcoholic extract of Achyranthes bidentata blume on acute and sub acute inflammation. The anti-inflammatory activities of the extracts were determined by measuring the inhibitory effect of the extracts on the activities of the pro-inflammatory enzyme, lipoxygenase and inducible nitric oxide synthase. The footpad volumes were measured immediately before the experiment time zero and every hour until 6-hour post-carrageenan injection. Disclosure The author reports no conflicts of interest in this work. Lipoxygenases are lipid-peroxidizing enzymes involved in the biosynthesis of leukotriene from arachidonic acid, mediators of inflammatory and allergic reactions. Flavonoids are a group of polyphenols thought to inhibit the biosynthesis of prostaglandins, end-products in the COX and LOX pathways of immunologic responses [ 13 ]. As part of documentation of medicinal plants used in Namibia, Zhen et al reported that local herbalists in Namibia use the leaves and roots of Ximenia caffra for various disease conditions. London: Biological and therapeutic properties attributed to these plant metabolites include antioxidant, anti-inflammatory, antimicrobial and anticancer activities [ 10 ]. Rats in group C received a graded dose of the aqueous extract of H. One of the functions of NO is to enhance the bactericidal and tumoricidal activities of activated macrophages [ 25 , 26 ]. Ghana The COX enzymes convert arachidonic acid to prostaglandin.
Effect of alcoholic extract of Achyranthes bidentata blume on acute and sub acute inflammation.
based on 22 review